Survival and pulmonary function in stage IA non‐small cell lung cancer after sublobar resection versus lobectomy: An updated meta‐analysis

• Published in: Journal of surgical oncology Vol. 130; no. 3; pp. 523 - 532
• Main Authors: Mamede, Isadora, Ribeiro, Leonardo, Stecca, Carlos, Escalante‐Romero, Lorena, Cypel, Marcelo
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-09-2024
• Subjects: Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - surgery; Humans; lobectomy; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Neoplasm Staging; non‐small cell lung carcinoma; Pneumonectomy - methods; Pneumonectomy - mortality; segmentectomy; survival analyses; Survival Rate; survival analyses; lobectomy; segmentectomy; non‐small cell lung carcinoma
• ISSN: 0022-4790; 1096-9098; 1096-9098
• DOI: 10.1002/jso.27767

Traditionally, lobectomy was standard for stage IA non‐small‐cell lung cancer (NSCLC). Recent RCTs suggest sublobar resection's comparable outcomes. Our meta‐analysis, incorporating 30 studies (including four RCTs), assessed sublobar resection's efficacy. Employing a random‐effects model and I2 statistics for heterogeneity, we found sublobar resection reduced DFS (HR 1.31, p < 0.01) and OS (HR 1.27, p < 0.01) overall. However, RCT subgroup analysis showed no significant differences in DFS (p = 0.28) or OS (p = 0.62). Sublobar resection is a viable option for well‐selected patients.