Association of KLF14 rs4731702 gene polymorphism with metabolic phenotype in young patients with type 1 diabetes

• Published in: Diabetes, obesity & metabolism Vol. 26; no. 9; pp. 3663 - 3672
• Main Authors: Ryba‐Stanisławowska, Monika, Słomiński, Bartosz, Myśliwiec, Małgorzata
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-09-2024; Wiley Subscription Services, Inc
• Subjects: Alleles; Blood pressure; CD25 antigen; CD4 antigen; Cholesterol; Diabetes; Diabetes mellitus (insulin dependent); Dyslipidemia; Gene frequency; Gene polymorphism; genetic polymorphism; Genotyping; Hemoglobin; Hypertension; Inflammation; KLF14; Lymphocytes T; metabolic phenotype; Metabolic syndrome; Metabolism; Phenotypes; Polymorphism; Single-nucleotide polymorphism; type 1 diabetes; type 1 diabetes; inflammation; KLF14, genetic polymorphism; metabolic phenotype
• ISSN: 1462-8902; 1463-1326; 1463-1326
• DOI: 10.1111/dom.15707

Aim
To explore the potential association between the KLF14 rs4731702 polymorphism and metabolic syndrome traits among patients diagnosed with type 1 diabetes (T1D).
Methods
The study group included 350 patients with T1D and 250 healthy control subjects. The analysis focused on the genotyping of KLF14 rs4731702 single nucleotide polymorphism (SNP), as well as evaluating serum concentrations of inflammatory markers, blood pressure, lipid profiles, and the quantitative status of CD4 + CD25highFOXP3+ T cells.
Results
Patients with T1D carrying the T allele of KLF14 rs4731702 SNP had higher high‐density lipoprotein cholesterol, lower low‐density lipoprotein cholesterol, as well as lower glycated haemoglobin and serum concentration of proinflammatory markers than C allele carriers. They also developed hypertension less often than carriers of the C allele. The analysis of CD4 + CD25highFOXP3+ regulatory T‐cell status based on KLF14 genotype showed that, in T1D patients, those with the TT genotype had the highest frequency of these cells compared to carriers of the CC and CT genotypes.
Conclusion
Our study suggests that the T allele of the KLF14 rs4731702 SNP might confer a protective effect against the development of obesity, hypertension, dyslipidaemia, and chronic inflammatory state in patients diagnosed with T1D.