Potential Implication of HLA-DQ Heterodimer High-Resolution Typing on Kidney Transplant Outcomes and Equity

Potential Implication of HLA-DQ Heterodimer High-Resolution Typing on Kidney Transplant Outcomes and Equity

Purpose of Review To evaluate the potential implications of HLA-DQαβ heterodimer high-resolution typing on clinical decision-making in solid organ transplantation. Recent Finding Lack of HLA-DQαβ heterodimer high-resolution typing information impacts cPRA calculations for patients on the waitlist an...

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Bibliographic Details
Published in:Current transplantation reports Vol. 10; no. 4; pp. 230 - 236
Main Authors: Maguire, Chelsea, Tambur, Anat R.
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01-12-2023
Subjects:
Immunology
Medicine
Medicine & Public Health
Surgery
Topical Collection on OPTN Policy
Transplant Surgery
cPRA
Compatible donor
HLA-antibody
Donor-specific antibody
Virtual crossmatch
HLA-DQ
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Summary:Purpose of Review To evaluate the potential implications of HLA-DQαβ heterodimer high-resolution typing on clinical decision-making in solid organ transplantation. Recent Finding Lack of HLA-DQαβ heterodimer high-resolution typing information impacts cPRA calculations for patients on the waitlist and thus can affect their priority in organ allocation algorithms. It can further affect the number of potential compatible organ offers that they can receive. Summary We believe that the compiled data highlight the need for a thorough evaluation by the OPTN/UNOS, to assure equity for patients in need of organ transplantation.
ISSN:2196-3029
2196-3029
DOI:10.1007/s40472-023-00407-3