The Anti-angiogenic and Anti-microbial Effect of Diosmin: Potential Receptor Interactions via Molecular Docking

• Published in: Revista brasileira de farmacognosia Vol. 33; no. 2; pp. 422 - 431
• Main Authors: Şimşek, Ece, Koçak, Orhan, Yıldırım, Kübra, Kuruoğlu, Aykut, Taşkın, Nazlı Deniz, Bozkurt, Serhat, İmir, Nilüfer, Ataş, Cemilenur, Akçit, Esra Tanyel, Çoban, Mustafa, Çoban, Ahmet Yılmaz
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-04-2023
• Subjects: Medicine; Original Article; Pharmacy; Hormone receptors; OmpA; Binding modes, Flavonoid; Molecular modeling; VEGF-VEGFR
• ISSN: 1981-528X; 1981-528X
• DOI: 10.1007/s43450-023-00365-y

This study examined the antiangiogenic capacity of diosmin
in vitro
and their interactions with certain important receptors related to cancer and infectious diseases via molecular docking. Diosmin, a naturally occurring flavone glycoside, largely found in citrus fruits, exhibits potentially antiangiogenic properties especially interacting with both VEGF and VEGFR. Treatment with certain doses of diosmin caused a reduction with a ratio of 22–68% on VEGF levels as compared to non-treated control groups. Western blotting and real-time PCR results demonstrated that protein expression of VEGF was downregulated in a dose- and time-dependent manner. On the other hand, we aimed to check the possible interaction of diosmin with VEGF, VEGFR, HER, PR, ER, and Omp-a, receptor proteins. According to our molecular docking results, diosmin effectively binds these receptors and probably this could be one of the possible reasons for its anti-angiogenic and anti-microbial properties.
Graphical Abstract