Photonic‐Plasmonic Coupling Enhanced Fluorescence Enabling Digital‐Resolution Ultrasensitive Protein Detection (Small 44/2023)

Photonic‐Plasmonic Coupling Enhanced Fluorescence Enabling Digital‐Resolution Ultrasensitive Protein Detection (Small 44/2023)

Digital‐Resolution Ultrasensitive Protein Detection The synergistic coupling between a plasmonic nanostructure and a photonic crystal resonator enables a 52‐fold improvement in the emission intensity of fluorescent dye molecules due to strong near‐field enhancement, improved extraction efficiency, a...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Vol. 19; no. 44
Main Authors: Barya, Priyash, Xiong, Yanyu, Shepherd, Skye, Gupta, Rohit, Akin, Lucas D., Tibbs, Joseph, Lee, Hankeun, Singamaneni, Srikanth, Cunningham, Brian T.
Format: Journal Article
Language:English
Published: Weinheim Wiley Subscription Services, Inc 01-11-2023
Subjects:
biosensors
Coupling
Digital imaging
fluorescence
Fluorescent dyes
immunoassay
Nanotechnology
Photonic crystals
photonics
Plasmonics
Proteins
Spontaneous emission
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Summary:Digital‐Resolution Ultrasensitive Protein Detection The synergistic coupling between a plasmonic nanostructure and a photonic crystal resonator enables a 52‐fold improvement in the emission intensity of fluorescent dye molecules due to strong near‐field enhancement, improved extraction efficiency, and an increased rate of spontaneous emission. This substantial boost in signal‐to‐noise ratio allows for the imaging and digital counting of human interleukin‐6 with a 10 fg mL−1 limit of detection and a 7‐log dynamic range. More details can be found in article number 2207239 by Srikanth Singamaneni, Brian T. Cunningham, and co‐workers.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202370370