Certain patterns of karyotype evolution in chronic myelogeneous leukaemia. Chromosome abnormalities in CML

The study of chromosome banding pattern of leukaemic cells in 15 patients with CML revealed t(9;22) in all cases. Similar additional chromosome abnormalities were observed in the terminal stage of the disease in 5 of 9 patients with aneuploid cell lines. The most frequent abnormalities were i(17q) a...

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Bibliographic Details
Published in:	Human genetics Vol. 30; no. 2; pp. 113 - 119
Main Authors:	Prigogina, E L, Fleischman, E W
Format:	Journal Article
Language:	English
Published:	Germany 06-11-1975
Subjects:	Adult Chromosome Aberrations Chromosome Deletion Chromosomes, Human, 16-18 Chromosomes, Human, 19-20 Chromosomes, Human, 21-22 and Y Chromosomes, Human, 6-12 and X Female Humans Leukemia, Myeloid - genetics Male Middle Aged Translocation, Genetic Trisomy
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Summary:	The study of chromosome banding pattern of leukaemic cells in 15 patients with CML revealed t(9;22) in all cases. Similar additional chromosome abnormalities were observed in the terminal stage of the disease in 5 of 9 patients with aneuploid cell lines. The most frequent abnormalities were i(17q) and trisomy 8. The regularities of karyotype evolution in the terminal stage of CML are discussed.
ISSN:	0018-7348 0340-6717 1432-1203
DOI:	10.1007/BF00291943