Validating the nutraceutical and neuroprotective pharmacodynamics of flavones

• Published in: Neurochemistry international Vol. 180; p. 105829
• Main Authors: Jeyabalan, Jeyaram Bharathi, Pathak, Suhrud, Mariappan, Esakkimuthukumar, Mohanakumar, K.P., Dhanasekaran, Muralikrishnan
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-11-2024
• Subjects: 7,8-Dihydroxyflavone; Flavones; Neurodegeneration; Neuroinflammation; Neurotrophic effect; Nutraceutical; Neurotrophic effect; Neuroinflammation; Flavones; Neurodegeneration; 7,8-Dihydroxyflavone; Nutraceutical
• ISSN: 0197-0186; 1872-9754; 1872-9754
• DOI: 10.1016/j.neuint.2024.105829

Neurodegenerative disorders are generally characterized by progressive neuronal loss and cognitive decline, with underlying mechanisms involving oxidative stress, protein aggregation, neuroinflammation, and synaptic dysfunction. Currently, the available treatment options only improve the symptoms of the disease but do not stop disease progression; neurodegeneration. This underscores the urgent need for novel therapeutic strategies targeting multiple neurodegenerative pathways alongside the conventional therapeutic strategies available.
Emerging evidence demonstrates that flavones a subgroup of flavonoids found abundantly in various dietary sources, have surfaced as promising candidates for neuroprotection due to their multifaceted pharmacological properties. Flavones possess the potency to modulate these pathophysiological processes through their antioxidant, anti-inflammatory, and neurotrophic activities. Additionally, flavones have been shown to interact with various cellular targets, including receptors and enzymes, to confer neuroprotection.
Though there are ample evidence available, the nutraceutical and neuroprotective pharmacodynamics of flavones have not been very well established. Hence, the current review aims to explores the therapeutic potential of flavones as nutraceuticals with neuroprotective effects, focusing on their ability to modulate key pathways implicated in neurodegenerative diseases. The current article also aims to actuate supplementary research into flavones as potential agents for alleviating neurodegeneration and improving patient outcomes in neurodegenerative disorders globally.
•Globally neurodegenerative disorders have become the leading cause of disability.•Pharmacodynamic properties of flavones are responsible for its therapeutic effects.•Flavones possess neurotrophic, neuroprotective, and neuro-regenerative effects.•7,8-DHF selectively binds to TrkB receptor and attenuates neurodegeneration.•Scientific exploration of flavones holds great promise to treat neurodegeneration.