Investigation of Antimicrobial, Cytotoxic, and Larvicidal Activities of Favipiravir

• Published in: ChemistrySelect (Weinheim) Vol. 8; no. 42
• Main Authors: Aydın, Hasan, Uslu, Uğur, Akocak, Süleyman, Lolak, Nebih, Sait, Ahmet, Korkmaz, Serol, Parmaksız, Ayşe, Ceylan, Onur, Aksakal, Abdulbaki
• Format: Journal Article
• Language: English
• Published: 13-11-2023
• ISSN: 2365-6549; 2365-6549
• DOI: 10.1002/slct.202303251

Abstract
Growing number of deaths due to decreased effects of antibiotics has increased the need for new antimicrobial drugs. Studies on the pharmacological effect and toxicity of favipiravir, a new antiviral drug that was informally recommended by World Health Organization (WHO) for the treatment of Coronavirus Disease 2019 (COVID‐19) for a while, are limited and still ongoing. We first aimed to evaluate the antibacterial efficacy of favipiravir in silico. A second aim of the manuscript is to examine its antibacterial, antifungal, cytotoxic, antiviral and larvicidal effects
in vitro
. In this study, it was determined that favipiravir was effective in terms of in silico antibacterial, in vitro antibacterial, antifungal, cytotoxicity, antiviral and larvicidal activities. As a result, potential areas of use can be found in terms of activities under investigation.