Eardrum perforation treatment blood plasma enriched with platelet growth factors

• Published in: Medicinskij sovet no. 12; pp. 110 - 115
• Main Authors: Kriukov, A. I., Gurov, A. V., Ermolaev, A. G., Murzakhanova, Z. V., Dubovaya, T. K., Bakhtin, A. A.
• Format: Journal Article
• Language: English; Russian
• Published: Remedium Group LLC 19-09-2021
• Subjects: hearing loss; post-traumatic otitis media; regeneration of the tympanic membrane; traumatic perforation of the tympanic membrane; tympanic membrane
• ISSN: 2079-701X; 2658-5790
• DOI: 10.21518/2079-701X-2021-12-110-115

Introduction
. The problem of the development of acute post-traumatic otitis media has not lost its relevance. Long-term preservation of the defect of the tympanic membrane contributes to the development of chronic inflammation in the middle ear and a deterioration in the quality of life of patients.
Objective
. To study the effect of blood plasma enriched with platelet growth factors on the regeneration of the tympanic membrane tissues in patients with acute post-traumatic perforation.
Materials and methods
. Patients with acute post-traumatic perforation of  the  tympanic membrane were divided into the main (24 people) and control (19 people) groups. Patients of the main group in the area of perforation of the tympanic membrane were injected once by application with a clot of autoplasma, enriched with platelet growth factors. The control group patients underwent dynamic observation of the processes of natural regeneration of the tympanic membrane tissues. On the 5, 10 and 15th days, the tissue regeneration of the tympanic membranes was assessed subjectively (patient complaints, audiometry) and objectively (otoscopy with the calculation of the dynamics of the relative perforation area, otoacoustic emission).
Results
. A single application of blood plasma enriched with platelet growth factors to the perforation area was significantly more often accompanied by closure of  the  tympanic membrane perforation (p ≤ 0.01) and a  decrease in  the  average relative area of the tympanic membrane perforation on days 10 and 15 of the study (p ≤ 0.01). The dynamics of the average relative area of the tympanic membrane perforation reflected a high rate of closure of the tympanic membrane defect in the main group. Better healing of the tympanic membrane in patients of the main group was accompanied by an improvement in the auditory function of the affected ear. The quality of hearing was, on average, significantly better in the patients of the main group than in the patients of the control group, both on the 10th and 15th days of observation (p ≤ 0.01).
Conclusion
. Clinical use of blood plasma enriched with platelet growth factors has a beneficial effect on the rate, intensity of closure of the tympanic membrane perforation and hearing.