Cancer Therapy: Folic Acid Functionalized Surface Highlights 5-Methylcytosine-Genomic Content within Circulating Tumor Cells (Small 21/2014)

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 10; no. 21; p. 4412
• Main Authors: Malara, Natalia, Coluccio, Maria Laura, Limongi, Tania, Asande, Monica, Trunzo, Valentina, Cojoc, Gheorghe, Raso, Cinzia, Candeloro, Patrizio, Perozziello, Gerardo, Raimondo, Raffaella, De Vitis, Stefania, Roveda, Laura, Renne, Maria, Prati, Ubaldo, Mollace, Vincenzo, Di Fabrizio, Enzo
• Format: Journal Article
• Language: English
• Published: Blackwell Publishing Ltd 01-11-2014
• Subjects: Circulating; Folic acid; folic acid receptors; functionalized surfaces; hyper-methylated circulating tumor cells; Monitoring; Scanning electron microscopy; Strategy; Tumors
• ISSN: 1613-6810; 1613-6829
• DOI: 10.1002/smll.201470135

A folic acid (FA)‐functionalized surface, able to selectively entrap circulating tumor cell (CTC)‐expressing folic receptors, is developed by E. Di Fabrizio and co‐workers on page 4324. Since FA represents a good transducer highlighting the CTC global 5‐methylcytosine content, this functionalized surface represents an important tool to profile cellular methylation changes in tumor monitoring strategies. The image shows CTCs under a scanning electron microscope after fixation and metallization. Image credit: M. Orlando, R. Ruffilli, and V. Shalabaeva.