Analysis of Gene-Gene Interactions

The goal of this unit is to introduce epistasis, or gene-gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identi...

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Bibliographic Details
Published in:	Current protocols in human genetics Vol. 95; p. 1.14.1
Main Authors:	Cole, Brian S, Hall, Molly A, Urbanowicz, Ryan J, Gilbert-Diamond, Diane, Moore, Jason H
Format:	Journal Article
Language:	English
Published:	United States 01-10-2017
Subjects:	Algorithms Animals Epistasis, Genetic Gene Expression Regulation Genetic Association Studies - methods Genetic Predisposition to Disease Genomics - methods Humans Machine Learning Models, Statistical disease susceptibility epistasis gene-gene interaction complex genetic traits
Online Access:	Get more information
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Summary:	The goal of this unit is to introduce epistasis, or gene-gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identification of potential gene-gene interactions. Then, it reviews statistical and machine learning methods for discovering epistasis in the context of genetic studies of quantitative and categorical traits. This unit concludes with a discussion of meta-analysis, replication, and other topics of active research. © 2017 by John Wiley & Sons, Inc.
ISSN:	1934-8258
DOI:	10.1002/cphg.45