Navigation of Prenatal Care With Sex Discordance Between Cell-free DNA and Ultrasound Findings
The utilization of cell-free DNA (cfDNA) screening has expanded rapidly across the age spectrum of pregnant persons. With cfDNA’s widespread adoption, genetic fetal sex is now often known before a phenotypic assessment on anatomic survey. CfDNA detects sex discordance in 1/1500 to 2000 pregnancies....
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| Published in: | Clinical obstetrics and gynecology Vol. 66; no. 3; pp. 616 - 623 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
01-09-2023
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| Online Access: | Get full text |
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| Summary: | The utilization of cell-free DNA (cfDNA) screening has expanded rapidly across the age spectrum of pregnant persons. With cfDNA’s widespread adoption, genetic fetal sex is now often known before a phenotypic assessment on anatomic survey. CfDNA detects sex discordance in 1/1500 to 2000 pregnancies. Upon detection of sex discordance, lab error or other factors should first be assessed. Once other causes have been ruled out, this may indicate an underlying disorder/difference in sex development. A multidisciplinary team should coordinate diagnosis, treatment, and support for the family. This review discusses the diagnostic workup, emphasizing the multidisciplinary counseling and management of disorder/differences in sex development. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 0009-9201 1532-5520 |
| DOI: | 10.1097/GRF.0000000000000802 |