Synthesis and Crystal Structure Determination of Cyclosporin H

• Published in: Collection of Czechoslovak chemical communications Vol. 65; no. 8; pp. 1317 - 1328
• Main Authors: Jegorov, Alexandr, Cvak, Ladislav, Husek, Aleš, Šimek, Petr, Heydová, Anna, Ondráček, Jan, Pakhomova, Svetlana, Hušák, Michal, Kratochvíl, Bohumil, Sedmera, Petr, Havlíček, Vladimír
• Format: Journal Article
• Language: English
• Published: 2000
• ISSN: 0010-0765; 1212-6950
• DOI: 10.1135/cccc20001317

Acid-catalyzed degradation of cyclosporin A was studied in various solvents and products of reaction were monitored by HPLC. Identification of amino acids and their chirality were determined after hydrolysis and derivatization by GC-MS. Cyclosporin H was isolated as the principal product and its structure was determined by X-ray diffraction: Cyclosporin H- diethyl ether-water (1 : 0.5 : 1) crystallizes in the monoclinic space group
I2
with
a
= 12.338(2) Å,
b
= 18.963(2) Å,
c
= 34.074(3) Å, β = 96.47(2)°,
Z
= 4, and
V
= 7 921.4(17) Å
3
.