Effect of Xe/O2 Inhalation on Hemostasis in Experimental Thromboplastin Pneumonitis

• Published in: Bulletin of experimental biology and medicine Vol. 176; no. 6; pp. 731 - 735
• Main Authors: Fedorova, E. P., Filonova, M. V., Churin, A. A., Sandrikina, L. A., Fomina, T. I., Neupokoeva, O. V., Shepeleva, N. V., Nikiforov, P. E., Naumov, S. A., Udut, E. V., Naumov, S. S., Udut, V. V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-04-2024; Springer Nature B.V
• Subjects: Alveoli; Animals; Antithrombin; Biomedical and Life Sciences; Biomedicine; Body temperature; Cell Biology; Design of experiments; Edema; Fibrinogen; Gas exchange; Gases; Hemostasis; Inflammation; Inhalation; Internal Medicine; Laboratory Medicine; Lungs; Medical research; Oxygen consumption; Pathology; Pharmacology; Physiology; Pneumonitis; Prothrombin; Regenerative medicine; Surfactants; Thromboplastin; Thrombosis; Xenon; thromboplastin; lungs; xenon; hemostasis; pneumonitis
• ISSN: 0007-4888; 1573-8221; 1573-8221
• DOI: 10.1007/s10517-024-06098-9

We studied the effectiveness of Xe/O
2
mixture inhalation (30% Xe and 70% O
2
, 20 min for 5 days) in a model of experimental thromboplastin pneumonitis. Inhalation of the studied mixture decreased the intensity of the inflammatory process in the lung tissue assessed by the temperature response of animals, changed lung weight and lung weight coefficient. At acute stage of pneumonitis, an increase in xenon consumption was recorded due to its retention in the gas exchange zone and a natural decrease in oxygen consumption due to partial alveolar/capillary block. The formation of pneumonitis was accompanied by a pronounced procoagulant shift in the regulation system of the aggregate state of blood. The Xe/O
2
inhalations ensured physiologically optimal levels of prothrombin and activated partial thromboplastin time against the background of a moderate decrease in fibrinogen level throughout the experiment. At the same time, the activity of the natural anticoagulant antithrombin III increased from day 5 to day 14.