Synthesis and Resolution of Racemic 2-Amino-2'-hydroxy-1,1'-binaphthyl

Synthesis and Resolution of Racemic 2-Amino-2'-hydroxy-1,1'-binaphthyl

The title compound 3 has been prepared via a highly selective, Cu(II)-mediated cross-coupling of 2-aminonaphthalene 1 and 2-naphthol 2 and resolved into enantiomers via crystallization of diastereoisomeric salts with (1 S )-(+)-10-camphorsulfonic acid. The method has been optimized and the use of ch...

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Bibliographic Details
Published in:Collection of Czechoslovak chemical communications Vol. 61; no. 10; pp. 1520 - 1524
Main Authors: Smrčina, Martin, Vyskočil, Štěpán, Polívková, Jana, Poláková, Jana, Kočovský, Pavel
Format: Journal Article
Language:English
Published: 01-10-1996
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Summary:The title compound 3 has been prepared via a highly selective, Cu(II)-mediated cross-coupling of 2-aminonaphthalene 1 and 2-naphthol 2 and resolved into enantiomers via crystallization of diastereoisomeric salts with (1 S )-(+)-10-camphorsulfonic acid. The method has been optimized and the use of chromatography eliminated.
ISSN:0010-0765
1212-6950
DOI:10.1135/cccc19961520