Extracellular vesicles over adeno-associated viruses: Advantages and limitations as drug delivery platforms in precision medicine

Tissue-specific uptake and sufficient biodistribution are central goals in drug development. Crossing the blood-brain barrier (BBB) represents a major challenge in delivering therapeutics to the central nervous system (CNS). Since its discovery in the late 19th century, considerable efforts have bee...

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Bibliographic Details
Published in:	Advanced drug delivery reviews Vol. 190; p. 114535
Main Authors:	Yom-Tov, Nataly, Guy, Reut, Offen, Daniel
Format:	Journal Article
Language:	English
Published:	Netherlands 01-11-2022
Subjects:	Blood-Brain Barrier Dependovirus Drug Delivery Systems Extracellular Vesicles Humans Precision Medicine Tissue Distribution Extracellular vesicles Drug delivery Microenvironment Exosomes Neurodevelopmental disorders Mesenchymal stem cells
Online Access:	Get full text
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Summary:	Tissue-specific uptake and sufficient biodistribution are central goals in drug development. Crossing the blood-brain barrier (BBB) represents a major challenge in delivering therapeutics to the central nervous system (CNS). Since its discovery in the late 19th century, considerable efforts have been invested in an attempt to decipher the BBB structure complexity and plasticity. In parallel, another prevalent approach is to improve a delivery system by harnessing the biological machinery in an attempt to enhance therapeutic-agent permeability. Here, we review the advantages and limitations of using extracellular vesicles over AAV systems as a delivery system for therapy, focusing on neurodevelopmental disorders.
ISSN:	0169-409X 1872-8294
DOI:	10.1016/j.addr.2022.114535