Osmotic demyelination syndrome: central pontine and extrapontine myelinolysis in a patient in the early postpartum period. Clinical observation

• Published in: Nevrologii͡a︡, neĭropsikhiatrii͡a︡, psikhosomatika Vol. 15; no. 5; pp. 39 - 45
• Main Authors: Isakova, E. V., Stepanova, E. A., Kotov, S. V., Belova, Yu. A.
• Format: Journal Article
• Language: English
• Published: IMA-PRESS LLC 23-10-2023
• Subjects: central pontine and extrapontine myelinolysis; childbirth; osmotic demyelination syndrome; pregnancy
• ISSN: 2074-2711; 2310-1342
• DOI: 10.14412/2074-2711-2023-5-39-45

The article presents a review of the literature and a description of a clinical case of osmotic demyelination syndrome manifested by pontine and extrapontine myelinolysis in a 36-year-old woman after her third surgical preterm delivery. The reasons for the development of a demyelinating lesion of the central nervous system are discussed, and clinical cases described in world literature sources are presented. An analysis of the pathogenesis of the development of this disease in women during pregnancy, childbirth, and lactation is provided. The importance of this period in a woman's life as an independent significant risk factor for the development of osmotic demyelination syndrome is discussed.