Vanillylmandelic acid protects against reperfusion injury in an experimental animal model of myocardial infarction

• Published in: Pathophysiology (Amsterdam) Vol. 26; no. 3-4; pp. 343 - 347
• Main Authors: Kolentinis, Michalis K., Verginadis, Ioannis I., Simos, Yannis V., Vezyraki, Patra, Karkabounas, Spyridon C., Giannakopoulos, Xenophon, Evangelou, Angelos M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-09-2019
• Subjects: Reperfusion arrhythmia; Reperfusion injury; Vagal stimulation; Vanillylmandelic acid; VF; Reperfusion arrhythmia; EG; PVCs; CG; Vagal stimulation; Vanillylmandelic acid; VT; Reperfusion injury
• ISSN: 0928-4680; 1873-149X
• DOI: 10.1016/j.pathophys.2019.09.001

Vanillylmandelic acid, a catecholamine end-metabolite, has been shown to have several biological properties in previous studies, despite considered biologically inactive. We examined the potential effects of vanillylmandelic acid on the ischemic heart following myocardial infarction and reperfusion on a rat model. Thirty-four female Wistar rats were randomized into two groups, control and experimental. They were anesthetized and subjected to myocardial infarction through left anterior descending artery ligation. A previously studied dose of vanillylmandelic acid (10 mg/kg) was administered and the following parameters were studied during ischemia and reperfusion: a) mortality b) severity of ventricular tachyarrhythmias c) premature ventricular contractions and d) heart rate. Administration of vanillymandelic acid significantly reduced the severity of ventricular tachyarrhythmias and mortality rate during reperfusion, while it did not affect any other of the parameters studied. In conclusion, reperfusion injury was blunted through vanillylmandelic acid administration, which seems to be mediated by parasympathetic activation.