The Comparison of Serum Interleukin-8 Levels Based on Severity of Liver Cirrhosis

The Comparison of Serum Interleukin-8 Levels Based on Severity of Liver Cirrhosis

Background: The molecule known as Interleukin-8 (IL-8), a chemotactic leukocyte, has been found to have a crucial role in the perpetuation of the inflammatory environment that is associated with hepatitis B virus (HBV) infection, as well as in the development of liver cirrhosis and cancer. Objective...

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Bibliographic Details
Published in:Medicinski arhiv Vol. 78; no. 2; pp. 92 - 94
Main Authors: Rey, Imelda, Ys, Rustam, Sukatendel, Khairani
Format: Journal Article
Language:English
Published: Sarajevo Academy of Medical Sciences of Bosnia and Herzegovina 2024
Subjects:
Anticoagulants
Chemokines
Conflicts of interest
Consent
Cytokines
Hepatitis B
Hepatitis C
Immune system
Infections
Interferon
Internal medicine
Laboratories
Liver cancer
Liver cirrhosis
Liver diseases
Medicine
Neutrophils
Original Paper
Pathogenesis
Patients
Viral infections
Viruses
Sumatra
Indonesia
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Summary:Background: The molecule known as Interleukin-8 (IL-8), a chemotactic leukocyte, has been found to have a crucial role in the perpetuation of the inflammatory environment that is associated with hepatitis B virus (HBV) infection, as well as in the development of liver cirrhosis and cancer. Objective: The aim of this study was to carefully examine the role of IL-8 in the inflammatory reaction and to compare the levels based on the severity of liver cirrhosis. Methods: The study was conducted from February 2018 to September 2018 at the Gastroenterohepatology Division, Internal medicine Department, Faculty of Medicine, Universitas Sumatera Utara. The study was designed as an analytic comparative, cross-sectional study. The liver cirrhosis patients who participated in this study met the inclusion criteria and provided informed consent. Results: A total of 70 patients were included in the study, from which we identified 1 individual with child-pugh A, 28 individuals with child-pugh B, and 41 individuals with child-pugh C. The serum level of IL-8 was found to be 98 (11-320) (pg/ml). The IL-8 levels between child-pugh B and C patients did not exhibit any noteworthy differences during our analysis (p = 0.109, p>0.05). Conclusion: There is no notable inequality in the levels of IL-8 across different stages of liver cirrhosis.
ISSN:0350-199X
1986-5961
DOI:10.5455/medarh.2024.78.92-94