Regulation of Wnt/β-catenin signaling by herpesviruses

The Wnt/β-catenin signaling pathway is instrumental in successful differentiation and proliferation of mammalian cells. It is therefore not surprising that the herpesvirus family has developed mechanisms to interact with and manipulate this pathway. Successful coexistence with the host requires that...

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Bibliographic Details
Published in:	World journal of virology Vol. 5; no. 4; pp. 144 - 154
Main Authors:	Zwezdaryk, Kevin J, Combs, Joseph A, Morris, Cindy A, Sullivan, Deborah E
Format:	Journal Article
Language:	English
Published:	United States Baishideng Publishing Group Inc 12-11-2016
Subjects:	Minireviews Varicella zoster virus Cytomegalovirus Kaposi’s sarcoma-associated herpesvirus Axin Glycogen synthase kinase-3 Wnt/β-catenin Epstein-Barr virus Herpes simplex virus-1 Herpesvirus
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Summary:	The Wnt/β-catenin signaling pathway is instrumental in successful differentiation and proliferation of mammalian cells. It is therefore not surprising that the herpesvirus family has developed mechanisms to interact with and manipulate this pathway. Successful coexistence with the host requires that herpesviruses establish a lifelong infection that includes periods of latency and reactivation or persistence. Many herpesviruses establish latency in progenitor cells and viral reactivation is linked to host-cell proliferation and differentiation status. Importantly, Wnt/β-catenin is tightly connected to stem/progenitor cell maintenance and differentiation. Numerous studies have linked Wnt/β-catenin signaling to a variety of cancers, emphasizing the importance of Wnt/β-catenin pathways in development, tissue homeostasis and disease. This review details how the alpha-, beta-, and gammaherpesviruses interact and manipulate the Wnt/β-catenin pathway to promote a virus-centric agenda.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Author contributions: Zwezdaryk KJ and Combs JA wrote the article, prepared the figures and tables; Morris CA and Sullivan DE outlined and edited the article. Correspondence to: Deborah E Sullivan, PhD, Associate Professor, Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Avenue, Mail Code 8638, New Orleans, LA 70112, United States. dsulliva@tulane.edu Telephone: +1-504-9886690 Fax: +1-504-9885144
ISSN:	2220-3249 2220-3249
DOI:	10.5501/wjv.v5.i4.144