Synthesis of trifluoromethylated α-hydroxy acids and their derivatives based on alkyl trifluoropyruvates

The reactions of trifluoropyruvates with nitromethane and arylmagnesium bromides leading to trifluoromethyl-containing α-hydroxy acid esters were studied and various derivatives of the acids were obtained.

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Bibliographic Details
Published in:	Russian chemical bulletin Vol. 67; no. 8; pp. 1426 - 1432
Main Authors:	Vasilyeva, T. P., Vorobyeva, D. V.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-08-2018 Springer Nature B.V
Subjects:	Bromides Chemistry Chemistry and Materials Science Chemistry/Food Science Derivatives Esters Hydroxy acids Inorganic Chemistry Nitromethane Organic Chemistry fluorine-containing α-hydroxy- and α-methoxycarboxylic acids and their derivatives alkylation methyl trifluoropyruvate α-hydroxy acid nitro derivatives ethyl trifluoropyruvate arylation
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Description
Summary:	The reactions of trifluoropyruvates with nitromethane and arylmagnesium bromides leading to trifluoromethyl-containing α-hydroxy acid esters were studied and various derivatives of the acids were obtained.
ISSN:	1066-5285 1573-9171
DOI:	10.1007/s11172-018-2235-z