The Sodium‐Induced Efflux of Calcium from Heart Mitochondria
The interrelations between the transport of Na+ and Ca2+ in heart mitochondria have been investigated. Na+ induces a partial release of Ca2+ from heart mitochondria; in the presence of ruthenium red the release of Ca2+ by Na+ is complete. The rate of Ca2+ release appears to be a function of [Na+]3 a...
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| Published in: | European journal of biochemistry Vol. 69; no. 2; pp. 453 - 462 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Oxford, UK
Blackwell Publishing Ltd
01-10-1976
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| Online Access: | Get full text |
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| Summary: | The interrelations between the transport of Na+ and Ca2+ in heart mitochondria have been investigated. Na+ induces a partial release of Ca2+ from heart mitochondria; in the presence of ruthenium red the release of Ca2+ by Na+ is complete. The rate of Ca2+ release appears to be a function of [Na+]3 and is stimulated by energy‐linked respiration. Ca2+ efflux is also induced by Li+ although Na+ is the preferred cation. The data are consistent with the existence of a system able to catalyze an exchange between Na+ (or Li+) and Ca2+ across the inner membrane of heart mitochondria. |
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| ISSN: | 0014-2956 1432-1033 |
| DOI: | 10.1111/j.1432-1033.1976.tb10930.x |