Patulignans A-C, three structurally unique lignans from the leaves of Melicope patulinervia

(±)-Patulignans A-C (1-3), three unique pairs of lignan enantiomers were isolated from the leaves of Melicope patulinervia. Patulignan A (1) possesses an unprecedented dimethyloxonane moiety in nature, meanwhile patulignans B (2) and C (3) are epimers carrying a novel dimethyl-1,6-dioxaspiro[4.5]dec...

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Bibliographic Details
Published in:	Organic & biomolecular chemistry Vol. 18; no. 34; p. 6607
Main Authors:	Vu, Van-Tuan, Nguyen, Manh-Tuyen, Wang, Wen-Li, Nguyen, Bich-Ngoc, Pham, Giang-Nam, Kong, Ling-Yi, Luo, Jian-Guang
Format:	Journal Article
Language:	English
Published:	England 14-09-2020
Subjects:	alpha-Glucosidases - metabolism Circular Dichroism Glycoside Hydrolase Inhibitors - chemistry Glycoside Hydrolase Inhibitors - isolation & purification Glycoside Hydrolase Inhibitors - pharmacology Lignans - chemistry Lignans - isolation & purification Lignans - pharmacology Molecular Conformation Molecular Structure Plant Leaves - chemistry Rutaceae - chemistry Stereoisomerism
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Summary:	(±)-Patulignans A-C (1-3), three unique pairs of lignan enantiomers were isolated from the leaves of Melicope patulinervia. Patulignan A (1) possesses an unprecedented dimethyloxonane moiety in nature, meanwhile patulignans B (2) and C (3) are epimers carrying a novel dimethyl-1,6-dioxaspiro[4.5]decane skeleton. Their structures were established by spectroscopy methods and electronic circular dichroism (ECD) calculations. Compounds 1-3 showed significant inhibitory activity against α-glucosidase.
ISSN:	1477-0539
DOI:	10.1039/d0ob01412e