Numerical modeling of mutual synchronization of auto-oscillations of epidermal proliferative activity in lesions of psoriatic skin

Numerical modeling of mutual synchronization of auto-oscillations of epidermal proliferative activity in lesions of psoriatic skin

The results of numerical modeling of mutual synchronization of self-oscillations of epidermal hyperproliferation in psoriatic foci are presented. It is shown that this phenomenon enables one to explain some specific features of the disease such as: (i) figured arrangement of pathological elements; (...

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Bibliographic Details
Published in:Biophysics (Oxford) Vol. 54; no. 4; pp. 519 - 524
Main Authors: Laptev, M. V., Nikulin, N. K.
Format: Journal Article
Language:English
Published: Dordrecht SP MAIK Nauka/Interperiodica 01-08-2009
Springer Nature B.V
Subjects:
Biological and Medical Physics
Biophysics
Complex Systems Biophysics
Numerical analysis
Physics
Physics and Astronomy
Psoriasis
Skin
psoriasis
proliferative activity
autooscillations
epidermis
numerical modeling
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Summary:The results of numerical modeling of mutual synchronization of self-oscillations of epidermal hyperproliferation in psoriatic foci are presented. It is shown that this phenomenon enables one to explain some specific features of the disease such as: (i) figured arrangement of pathological elements; (ii) sudden exacerbation of the process soon after treatment; (iii) persistence of lesions in a limited region of the skin or, vice versa, their rapid spread over the body surface.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350909040198