Synthesis and antimicrobial activity of β-N-acylhydrazides of 4-aryl-2-hydroxy-4-oxo-2-butenoic (aroylpyruvic) acids

Synthesis and antimicrobial activity of β-N-acylhydrazides of 4-aryl-2-hydroxy-4-oxo-2-butenoic (aroylpyruvic) acids

A series of β-N-acylhydrazides of 4-aryl-2-hydroxy-4-oxo-2-butenoic (aroylpyruvic) acids have been synthesized in 80-90% yield via decyclization reactions of 5-aryl-2,3-dihydrofuran-2,3-diones with hydrazides of aromatic acids in anhydrous dioxane. Physicochemical characteristics of the products wer...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal Vol. 42; no. 9; pp. 527 - 528
Main Authors: Zvereva, O. V, Milyutin, A. V, Odegova, T. F, Fedorenko, E. N
Format: Journal Article
Language:English
Published: Boston Boston : Springer US 01-09-2008
Springer US
Subjects:
Medicine
Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Antimicrobial Activity
Flumequine
Diketo
Hydrazide
Nalidixic Acid
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Summary:A series of β-N-acylhydrazides of 4-aryl-2-hydroxy-4-oxo-2-butenoic (aroylpyruvic) acids have been synthesized in 80-90% yield via decyclization reactions of 5-aryl-2,3-dihydrofuran-2,3-diones with hydrazides of aromatic acids in anhydrous dioxane. Physicochemical characteristics of the products were determined. Their antimicrobial properties were examined.
Bibliography:http://dx.doi.org/10.1007/s11094-009-0174-6
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-009-0174-6