The Influence of Pressure in Paracetamol Tablet Compaction on 14N Nuclear Quadrupole Resonance Signal

• Published in: Applied magnetic resonance Vol. 44; no. 6; pp. 735 - 743
• Main Authors: Lužnik, J., Pirnat, J., Jazbinšek, V., Lavrič, Z., Srčič, S., Trontelj, Z.
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01-06-2013; Springer Nature B.V
• Subjects: Analgesics; Atoms and Molecules in Strong Fields; Counterfeiting; Electric fields; Laser Matter Interaction; Manufacturers; Nitrogen; Nuclear quadrupole resonance; Organic Chemistry; Physical Chemistry; Physics; Physics and Astronomy; Quadrupoles; Room temperature; Signal to noise ratio; Solid State Physics; Spectroscopy/Spectrometry; Spectrum analysis; Tablets; Active Pharmaceutical Ingredient; Nuclear Quadrupole Resonance Frequency; Nuclear Quadrupole Resonance; Compaction Pressure
• ISSN: 0937-9347; 1613-7507
• DOI: 10.1007/s00723-013-0440-3

14
N nuclear quadrupole resonance (
14
N NQR) of several commercially available paracetamol tablets was measured. The spectra of two polymorphs are presented. The linewidths of the correspondent
14
N NQR lines in all the measured samples containing the room-temperature stable monoclinic polymorph were noticeably different. We proved experimentally that the linewidth differences are the consequence of different compacting pressure in the production of tablets.