Glandular odontogenic cyst: a case report

• Published in: Oral surgery Vol. 1; no. 4; pp. 223 - 227
• Main Authors: De Castro, J.F.L., Henriques, Á.C.G., Medeiros, M.D., Montenegro, L.T., Cazal, C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-11-2008
• Subjects: glandular odontogenic cyst; odontogenic cyst; odontogenic neoplasm
• ISSN: 1752-2471; 1752-248X
• DOI: 10.1111/j.1752-248X.2008.00040.x

The glandular odontogenic cyst (GOC) is a rare developmental lesion considered a distinct entity because of its uncommon histopathological characteristics. It has morphological similarities to other lesions, which makes its histopathological diagnosis challenging for some pathologists. This lesion can involve either jaws, but the anterior region of the mandible is the most affected area. It strikes distinct age groups, with an average patient age of 50 years. It can exhibit a tendency towards recurrence when conservative treatment is administered. It is believed that the low prevalence of GOC in the literature is because of not only its rarity, but principally to the fact that its main characteristics are also found in other pathological entities, thereby generating controversial diagnoses. The aim of the present article is to report a case of GOC in a 40‐year‐old female patient exhibiting an intrabone cyst in the anterior mandibular region. The initial diagnostic hypothesis by means of radiographic imaging was of a traumatic bone cyst. After histological analysis, the lesion was diagnosed as GOC. The specimen was stained with haematoxylin and eosin, and then with the Periodic Acid Schiff (PAS) method. Through immunohistochemical analysis, the cyst tested positively for the Ki‐67 and p53 antibodies as well as high molecular pan‐cytokeratin.