Comparative Characteristics of Inactivation Agents for HFRS Vaccine Development

Comparative Characteristics of Inactivation Agents for HFRS Vaccine Development

The results of various methods of Puumala virus inactivation, including ultraviolet rays (UV), β -propiolactone (BPL) and formalin are presented. Immunogenicity of vaccine preparations obtained using these virus inactivation methods did not differ significantly in the experiments on BALB/c mice. Ess...

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Bibliographic Details
Published in:Èpidemiologiâ i vakcinoprofilaktika (Online) Vol. 17; no. 4; pp. 26 - 29
Main Authors: Kurashova, C. C., Ishmukhametov, A. A., Egorova, M. C., Balovneva, M. V., Dzagurova, T. K., Tkachenko, E. A.
Format: Journal Article
Language:English
Published: Numikom LLC 19-09-2018
Subjects:
formalin
hemorrhagic fever with renal syndrom (hfrs)
inactivation
real-time pcr
uv rays
vaccine
virus
β-propiolactone
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Summary:The results of various methods of Puumala virus inactivation, including ultraviolet rays (UV), β -propiolactone (BPL) and formalin are presented. Immunogenicity of vaccine preparations obtained using these virus inactivation methods did not differ significantly in the experiments on BALB/c mice. Essential advantage of UV and BPL in relation to formaldehyde is the short time of virus inactivation.
ISSN:2073-3046
2619-0494
DOI:10.31631/2073-3046-2018-17-4-26-29