Antiviral Activity of Kagocel® in vitro Against Virus SARS-CoV-2

Antiviral Activity of Kagocel® in vitro Against Virus SARS-CoV-2

The antiviral activity of the drug Kagocel®, which has a high safety profile and proven efficacy for the prevention and treatment of influenza and AVRI as an interferon inducer, was studied against a new pandemic strain of SARS-CoV-2 in vitro in Vero C1008 cell culture. The results of the study reve...

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Bibliographic Details
Published in:Антибиотики и Химиотерапия Vol. 65; no. 3-4; pp. 3 - 6
Main Authors: S. Ya. Loginova, V. N. Shchukina, S. V. Savenko, S. V. Borisevich
Format: Journal Article
Language:English
Published: LLC "Publishing House OKI" 07-06-2020
Subjects:
antiviral activity
covid-19
in vitro
kagocel
sars-cov-2
vero
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Summary:The antiviral activity of the drug Kagocel®, which has a high safety profile and proven efficacy for the prevention and treatment of influenza and AVRI as an interferon inducer, was studied against a new pandemic strain of SARS-CoV-2 in vitro in Vero C1008 cell culture. The results of the study revealed that at the addition of the substance Kagocel® at the concentration of 5000 pg/ml into the cell culture 1 h before the virus infection and 1 h after, there was 100% inhibition of the cytopathic activity of the virus. It was also found that Kagocel® at the dose of 5000 pg/ml effectively suppressed the reproduction of the SARS-CoV-2 virus, vari­ant B, in Vero C1008 cell culture by 1.75 lg, the inhibition coefficient was 97.83 %.
ISSN:0235-2990
DOI:10.37489/0235-2990-2020-65-3-4-3-6