Vitamin D and women’s reproductive health (literature review)

• Published in: Medicinskij sovet no. 12; pp. 164 - 172
• Main Authors: Ya. Z. Zaydieva, V. E. Balan
• Format: Journal Article
• Language: English
• Published: Remedium Group LLC 29-07-2018
• Subjects: fertility; polycystic ovary syndrome; vitamin d receptor
• ISSN: 2079-701X; 2658-5790
• DOI: 10.21518/2079-701X-2018-12-164-172

Vitamin D and women’s reproductive health (literature review). Literature search the relationship between vitamin D and fertility in women рerformed in Pubmed. The vitamin D receptor (VDR) and vitamin D metabolizing enzymes are found in reproductive tissues of women. Moreover, we present evidence that vitamin D is involved in female reproduction including IVF outcome and polycystic ovary syndrome (PCOS). In PCOS women, low 25-hydroxyvitamin D (25(OH)D) levels are associated with obesity, metabolic, and endocrine disturbances and vitamin D supplementation might improve menstrual frequency and metabolic disturbances in those women. Moreover, vitamin D might influence steroidogenesis of sex hormones (estradiol and progesterone) in healthy women and high 25(OH)D levels might be associated with endometriosis.