Cutaneous sinus histiocytosis of face of the non-Langerhans cell histiocytoses type (cutaneous Rosai — Dorfman disease)

• Published in: Vestnik dermatologij i venerologij Vol. 94; no. 5; pp. 66 - 71
• Main Authors: Sokolovsky, E. V., Mikheev, G. N., Rybakova, M. G., Manasheva, E. B., Seredina, V. A.
• Format: Journal Article
• Language: English
• Published: State Scientific Center of Dermatovenereology and Cosmetology 01-02-2019
• Subjects: cutaneous form; diagnostics; emperipolesis; immunohistochemistry (ihc) assay for biopsy samples; sinus histiocytosis of the non-langerhans cell histiocytoses type
• ISSN: 0042-4609; 2313-6294
• DOI: 10.25208/0042-4609-2018-94-5-66-71

An extremely rare case of sinus histiocytosis of the non-Langerhans cell histiocytoses type is described in 55-year-old patient with isolated localization of cutanious lesion on the right cheek without involvement of nodular structures. Main skin lesion was an erythematous-cyanotic node with multiple milia-like lesions on the top of it. Histologically revealed feature was a large number of plasma cells, besides phenomenon of emperipolesis was described, which was first falsely perceived by pathologists as phagocytosis. In immu-nohistochemistry assay the changes were characterized by proliferation of large polygonal histiocytes with accumulation of pentalamellar markers in its cytoplasm (protein S-100, CD68).