In vitro antitumor effects of aqueous extract and protease inhibitors from Sterculia striata st. Hil. et naud and metabolite profiling

• Published in: Natural product research pp. 1 - 6
• Main Authors: Junior, Tadeu F Braga, Lima, Nerilson M, Carli, Gabriela P, M Cachuba, Roberta, J Guarneire, Gracimério, J Tabai, Beatriz, M Abrão, Roberta, G Barbosa, Samuel, Machado, Lucas S, S Nunes, Jander, S Machado, Fabiana, Andrade, Teresinha de Jesus A S, Br Castro, Sandra, Vaz, Boniek G, A Amaral, Ernani, S Alves, Caio Cesar, Carli, Alessandra P
• Format: Journal Article
• Language: English
• Published: England 06-02-2024
• Subjects: breast cancer; Sterculia striata; bioactive metabolites; cytotoxicity
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2024.2302326

The present study aims to assess the cytotoxic effect of the aqueous and protease inhibitors extracts of
on breast cancer cell lines. The
results showed significant reductions in the highest concentrations from the
seed extract for all cell lines. The aqueous extract reduced the viability by up to 35% in the MCF-7, 25% in the 4T1, and 35% in the MDA-MB-231 cell lines. Regarding the protease inhibitor extract, a 50% reduction in cell viability was observed in the MDA-MB-231 at concentration of 333 µg/mL. The aqueous and the protease inhibitor extracts showed mild reduction in the viability of macrophage cell lines. Chemical characterisation analysis revealed several polyphenols such as flavonoids, tannins, phenolic acids, and other secondary metabolites including terpenes, steroids, fatty acids, and organic acids, which may be related to the promising bioactivity observed. The
showed antitumor activity, emphasising its pharmacological potential.