Role of circulating angiogenic factors in diabetic kidney disease

• Published in: Vestnik Rossiĭskoĭ akademii medits︠i︡nskih nauk no. 2; p. 35
• Main Authors: Martynov, S A, Shestakova, M V, Kutyrina, I M, Il'in, A V, Arbuzova, M I, Dedov, I I
• Format: Journal Article
• Language: English
• Published: Russia (Federation) 2013
• Subjects: Adult; Aged; Albuminuria - blood; Anemia - blood; Angiopoietin-1 - blood; Angiopoietin-2 - blood; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetic Nephropathies - blood; Diabetic Nephropathies - etiology; Glomerular Filtration Rate; Homeostasis; Humans; Middle Aged; Proteinuria - blood; Renal Insufficiency, Chronic - blood; Vascular Endothelial Growth Factor A - blood
• ISSN: 0869-6047
• DOI: 10.15690/vramn.v68i2.547

This original article contains the authors own data on homeostasis of angiogenic growth factors (vascular endothelial growth factor - VEGF, angiopoietin 1 and 2 - Ang-1, Ang-2) in diabetic kidney disease. The aims of study were evaluation of alteration on serum concentration of circulating VEGF, Ang-l and Ang-2, and of their association with markers of renal damage (albuminuria, glomerular filtration rate) and anemia in patients with diabetes mellitus. We studied 78 patients type I diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Among this group 37patients had chronic kidney disease. The serum level of VEGF was elevated in T1DM patients and was associated with degree of proteinuria. The serum concentration of Ang-2 was higher in patients with chronic kidney disease (T1DM and T2DM), renal failure (T1DM), proteinuria and anemia (T2DM). Ang-2 strongly associated with albuminuria (T1DM and T2DM), glomerular filtration rate (T1DM) and hemoglobin (T2DM). Obtained results demonstrate that levels of VEGF and Ang-2 (but not Ang-1) are raised in patients with diabetic kidney disease and associated with markers of renal damage and anemia. These data indicate the presence of the disturbance of angiogenic growth factors (VEGF, Ang-2) homeostasis and activity in diabetic patients with chronic kidney disease.