CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD

CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD

Induction of chronic GVHD in the DBA/2→(C57Bl/6xDBA/2) F1 semi-allogeneic murine model results into development of Th1- and Th2-dependent immunopathological conditions that are characterized by different cytokine profiles. Chronic GVHD is accompanied by a sharp increase in IgE levels, thus presuming...

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Bibliographic Details
Published in:Medit͡s︡inskai͡a︡ immunologii͡a Vol. 14; no. 1-2; pp. 67 - 74
Main Authors: Kudaeva, O. T., Tkachev, V. O., Gavrilova, E. D., Goiman, E. V., Volsky, N. N., Perminova, O. M., Kolesnikova, O. P.
Format: Journal Article
Language:English
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 19-07-2014
Subjects:
chronic gvhd
cytokines
immunoglobulin e
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Summary:Induction of chronic GVHD in the DBA/2→(C57Bl/6xDBA/2) F1 semi-allogeneic murine model results into development of Th1- and Th2-dependent immunopathological conditions that are characterized by different cytokine profiles. Chronic GVHD is accompanied by a sharp increase in IgE levels, thus presuming considerable IL-4 production. In recipients with Th2-dependent GvHD variant, elevated contents of serum IL-6, IL-7 and TNFα were also observed, which, along with other effects, may support polyclonal activation of B cells, thus leading to development of autoimmune pathology.
ISSN:1563-0625
2313-741X
DOI:10.15789/1563-0625-2012-1-2-67-74