Solubility of salbutamol and salbutamol sulphate in ethanol+water mixtures at 25°C

• Published in: Journal of molecular liquids Vol. 173; pp. 62 - 65
• Main Authors: Ali, Hany S.M., York, Peter, Blagden, Nicholas, Khoubnasabjafari, Maryam, Acree, William E., Jouyban, Abolghasem
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-09-2012
• Subjects: Ethanol + water; Salbutamol; Salbutamol sulphate; Solubility; Salbutamol; Salbutamol sulphate; Ethanol+water; Solubility
• ISSN: 0167-7322; 1873-3166
• DOI: 10.1016/j.molliq.2012.05.021

Experimental solubilities of salbutamol and salbutamol sulphate in ethanol+water mixtures at 25°C are reported. The solubility of salbutamol was found to increase with the addition of ethanol, and reached a maximum value at an ethanol volume fraction of 0.8. The solubility of salbutamol sulphate decreased with increasing ethanol concentration, and reached a minimum value in ethanol. The Jouyban–Acree model correlated the measured salbutamol and salbutamol sulphate solubility data to within mean relative deviations (MRD) of 3.4% and 13.4%, respectively. Solubilities were predicted using previously trained models developed for crystalline non-electrolyte and electrolyte solutes. The trained models for non-electrolytes and electrolytes produced the prediction MRDs of 22.4% and 19.8%, respectively.
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► Reporting the solubility data of salbutamol and salbutamol sulphate in ethanol+water mixtures at 25°C. ► Mathematical representation of the data in binary solvents using Jouyban–Acree model. ► Prediction of solubility data of base and salt forms of salbutamol using two previously proposed methods.