Physicochemical properties of the antihypertensive agent 2-benzylimidazoline in aqueous and physiological solutions at 25 and 37°C

• Published in: Journal of molecular liquids Vol. 196; pp. 285 - 290
• Main Authors: Romano, Elida, Castillo, María Victoria, Márquez, María Belén, Gramajo, Mónica Beatriz, Brandán, Silvia Antonia
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-08-2014
• Subjects: 2-Benzylimidazoline; Aqueous solution; Density; Physiological solution; Refractive index; Physiological solution; Aqueous solution; Density; Refractive index; 2-Benzylimidazoline
• ISSN: 0167-7322; 1873-3166
• DOI: 10.1016/j.molliq.2014.03.036

Physicochemical properties of aqueous and physiological solutions of the antihypertensive agent 2-benzylimidazoline (BI), such as pH, refractive index, viscosity, density, conductivity and molar refractivity properties were studied at 25 and 37°C in the concentration range 0.025–0.100M. Equations which describe the relative viscosity of the solutions have also been given and viscosity B coefficients using the Jones–Dole equation have been calculated and interpreted in terms of ion–solvent interactions. The computed pKb values in both media varied between 5.0 and 8.58, and correlate well with the available experimental results found in the literature. The experimental properties of the studied species are shown and discussed. It is concluded that the interactions between solute and solute (BI+ and BI) or between solute and solvent could explain the different variations for 2-benzylimidazoline in both media.
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•Physicochemical properties of 2-benzylimidazoline in aqueous and physiological solutions were studied at 25 and 37°C.•The physicochemical properties of 2-benzylimidazoline in both media were studied in the concentration range 0.025–0.100M.•The experimental properties of the studied species are shown and discussed.•The viscosity B coefficients have been calculated in both media and interpreted in terms of ion–solvent interactions.•The solute–solute or solute–solvent interactions could explain the variations in the properties observed in both media.