A chosen STING with a PERKy trail

Cytosolic DNA sensing by the cGAS–STING pathway is critical for sustaining an innate immune defense program. A new study shows that the cGAS–STING pathway signals by a non-canonical mechanism to control protein translation through the unfolded protein response sensor PERK, and thereby contributes to...

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Bibliographic Details
Published in:	Nature cell biology Vol. 24; no. 5; pp. 602 - 604
Main Authors:	Hazari, Younis, Hetz, Claudio
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-05-2022 Nature Publishing Group
Subjects:	631/250/262 631/337/574 631/80/304 631/80/509 Autoimmune diseases Biology Biomedical and Life Sciences Cancer Research Cardiomyopathy Cell Biology Chronic obstructive pulmonary disease Cyclin-dependent kinases Defense programs Developmental Biology DNA damage Fibrosis Immune system Kinases Life Sciences Liver diseases Lupus News & Views news-and-views Parkinson's disease Protein folding Proteins Senescence Sensors Stem Cells Transcription factors
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Summary:	Cytosolic DNA sensing by the cGAS–STING pathway is critical for sustaining an innate immune defense program. A new study shows that the cGAS–STING pathway signals by a non-canonical mechanism to control protein translation through the unfolded protein response sensor PERK, and thereby contributes to cellular senescence and organ fibrosis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1465-7392 1476-4679
DOI:	10.1038/s41556-022-00905-z