Analysis of biological properties of 1,2,4-triazole-containing compounds (literature review)

• Published in: Aktualʹnì pitannâ farmacevtičnoï ì medičnoï nauki ta praktiki Vol. 15; no. 1; pp. 102 - 106
• Main Authors: Khilkovets, A. V., Parchenko, V. V.
• Format: Journal Article
• Language: English
• Published: Zaporozhye State Medical University 01-04-2022
• Subjects: 1 2 4-triazole; activity; biological properties
• ISSN: 2306-8094; 2409-2932
• DOI: 10.14739/2409-2932.2022.1.252392

In the latest conditions of development and formation of the pharmaceutical industry, the introduction of new synthetic medicines requires continuous monitoring of the quality and safety of their use. For many years, synthetic drugs have remained an essential tool in the prevention and control of diseases of various etiologies. Among the synthetic class of substances, first of all, those that are low-toxic, safe, and effective deserve attention. In recent decades scientific publications prove the prospects of searching for new biologically active compounds among derivatives of 1,2,4-triazoles with fragments of various heterocyclic systems. Scientists claim that the combination of several structural fragments of heterocycles in one molecule leads to the emergence of new types of biological action, and sometimes to an increase in known pharmacological effects. At the same time, the synthesized compounds belong to the class of low-toxic or practically non-toxic substances.
The aim of our work is to analyze foreign and native sources on the biological activity of 1,2,4-triazole derivatives.
Conclusions. Among these derivatives, molecules that exhibit broad antifungal and antimicrobial activity, antitubercular, antiviral, actoprotective, antihypoxic, analgesic effects, etc. were found. After analyzing the known data, a number of «structure-action» regularities were established. The obtained results will be useful for further research work of scientists.