Multiple Facets and Roles of Na + -K + -Cl - Cotransport: Mechanisms and Therapeutic Implications

The Na -K -Cl cotransporters play key physiological and pathophysiological roles by regulating the membrane potential of many cell types and the movement of fluid across a variety of epithelial or endothelial structures. As such, they should soon become invaluable targets for the treatment of variou...

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Bibliographic Details
Published in:	Physiology (Bethesda, Md.) Vol. 35; no. 6; pp. 415 - 429
Main Authors:	Garneau, A P, Slimani, S, Fiola, M J, Tremblay, L E, Isenring, P
Format:	Journal Article
Language:	English
Published:	United States 01-11-2020
Subjects:	molecular mechanisms NKCC1 NKCC2 Na+-K+-Cl− cotransporters physiological roles cation-Cl− cotransporter
Online Access:	Get full text
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Summary:	The Na -K -Cl cotransporters play key physiological and pathophysiological roles by regulating the membrane potential of many cell types and the movement of fluid across a variety of epithelial or endothelial structures. As such, they should soon become invaluable targets for the treatment of various disorders including pain, epilepsy, brain edema, and hypertension. This review highlights the nature of these roles, the mechanisms at play, and the unresolved issues in the field.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1548-9213 1548-9221
DOI:	10.1152/physiol.00012.2020