The study of microcirculation and tissue metabolism as early diagnostic criteria for the risk of diabetic foot development

• Published in: Terapevtic̆eskii arhiv Vol. 94; no. 8; pp. 957 - 962
• Main Authors: Mkrtumyan, Ashot M., Zvenigorodskaya, Larissa A., Shinkin, Mikhail V.
• Format: Journal Article
• Language: English
• Published: 12-10-2022
• ISSN: 0040-3660; 2309-5342
• DOI: 10.26442/00403660.2022.08.201789

Aim. To assess the state of the microvasculature, tissue metabolism and its reserve capabilities for the purpose of early intervention for the prevention of diabetic foot syndrome.
Materials and methods. Thirty patients were examined. The patients were divided into three groups depending on the hypoglycemic therapy (metformin, empagliflozin, dapagliflozin). The comparison group consisted of 12 volunteers who did not have carbohydrate metabolism disorders.
Results. It was found: the HbA1c indicator significantly decreased in all three groups; significant dynamics in the state of the microvasculature was not observed in any of the three groups; in all groups, there was an improvement in tissue metabolism, however, in this case, no significant dynamics were observed in any of the 3 groups, which indicates the need for provocative tests.
Conclusion. For this purpose, the authors recommend the method of combined use of laser Doppler flowmetry and laser fluorescence spectroscopy. This technique allows diagnosing the state of the microvasculature and tissue metabolism and its reserve capabilities, using thermal and cold tests.