Relation of the heart remodeling and endothelial dysfunction in chronic heart failure patients

• Published in: Kardiovaskuli͡a︡rnai͡a︡ terapii͡a︡ i profilaktika Vol. 15; no. 1; pp. 16 - 19
• Main Authors: Abdullaeva, Ch. A., Kamilova, U. K.
• Format: Journal Article
• Language: English
• Published: SILICEA-POLIGRAF» LLC 01-02-2016
• Subjects: chronic heart failure; endothelial dysfunction; heart remodeling
• ISSN: 1728-8800; 2619-0125
• DOI: 10.15829/1728-8800-2016-1-16-19

Aim. To study relation of the heart remodeling processes and endothelial dysfunction in patients with chronic heart failure (CHF).Material and methods. Totally, 103 patients studied with post infarction cardiosclerosis. All patients selected to 3 groups by functional class (FC): I group consisted of 28 patients with CHF I FC, II — 46 patients with II FC and III — 29 patients with III FC by NYHA. All patients underwent echocardiography, dopplerography of brachial artery.Results. Post infarction remodeling of the left ventricle (LV) led notonly to structural remodeling of LV, with chamber dilation, wallsthinning, contractility decrease, but to changes of LV geometry.Contractility decrease of LV myocardium followed by the disorderedendothelium-dependent vessel dilation, with increase of pulsative andresistive indexes, sensitivity decrease of brachial artery to the shifttension.Conclusion. In CHF patients the processes of heart remodeling followed by remodeling of vessels, showing functional and humoral parameters of endothelial dysfunction.