Analysis of macrophage transcriptome in atherogenesis

• Published in: Rossiĭskiĭ kardiologicheskiĭ zhurnal no. 2; pp. 92 - 98
• Main Authors: Kubekina, M. V., Nikiforov, N. G., Karagodin, V. P., Sobenin, I. A., Orekhov, A. N.
• Format: Journal Article
• Language: English
• Published: FIRMA «SILICEA» LLC 07-03-2019
• Subjects: activation; atherosclerosis; gene expression; low density lipoproteins; macrophages; transcriptome analysis
• ISSN: 1560-4071; 2618-7620
• DOI: 10.15829/1560-4071-2019-2-92-98

The accumulation of cholesterol under the influence of modified low density lipoprotein is a key cause of atherogenesis. It is known that atherosclerosis is accompanied by chronic local inflammation. Monocytes/macrophages, main cells of the innate immunity, may not only capturing and accumulating lipids in the vascular wall, but also secreting signaling molecules that affect the functions of other cells. An atherosclerotic lesion is characterized by the inability to complete the inflammatory response, as a result of which the inflammation becomes chronic. Intracellular lipid accumulation is a necessary condition for the initiation of atherogenesis, but it is not known whether it is sufficient. Analysis of the transcriptome allowed us to characterize the state of macrophages loaded with lipids. Studies presented in this review show that the reaction of innate immunity contributes to the accumulation of intracellular lipids and aggravates it.