Epidemiological and molecular-genetic monitoring of rotavirus infection in the Orenburg region in the period predictively

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii Vol. 96; no. 2; pp. 30 - 36
• Main Authors: Akimkin, V. G., Gorelov, A. V., Podkolzin, A. T., Denisyuk, N. B.
• Format: Journal Article
• Language: English
• Published: Central Research Institute for Epidemiology 01-08-2019
• Subjects: children; genotypes; morbidity; rotavirus infection
• ISSN: 0372-9311; 2686-7613
• DOI: 10.36233/0372-9311-2019-2-30-36

Aim. To analyze the epidemiological situation of rotavirus infection in the Orenburg region, taking into account  the manifestations  of the epidemic  process and the molecular  genetic characteristics  of rotavirus group. Materials and methods. We рresented the results of epidemiological and molecular genetic monitoring of rotavirus infection in the period 2013-2017. Molecular genetic typing was performed in 232 fecal samples of patients under 3 years of age with rotavirus infection. Were used methods of retrospective epidemiological analysis, ELISA, PCR. Results. The incidence of high tear and had a tendency to increase. The most affected were children under 14 years of age. The genetic potential of the rotavirus population in the region was represented by ten main genotypes. The leading significance in the epidemic process were genotypes with the highest frequency of occurrence:  G4[P]8  (56,9%), G9[P]8  (12,9%), Mixt (8,6%), G2[P]4  (7,7%), G1[P]8  (6,5%). Conclusion. Were revealed a significant increase in the incidence of rotavirus infection among children. Were revealed the dominant genotypes of rotaviruses, their regional diversity and change during several seasons.