Constituintes químicos e atividade Leishmanicida de Gustavia elliptica (Lecythidaceae)

• Published in: Química Nova Vol. 34; no. 7; pp. 1182 - 1187
• Main Authors: Almeida, Maria de Fátima Oliveira, Melo, Ana Cláudia Rodrigues de, Pinheiro, Maria Lúcia Belém, Silva, Jefferson Rocha de Andrade, Souza, Afonso Duarte Leão de, Barison, Andersson, Campos, Francinete Ramos, Amaral, Ana Cláudia Fernandes, Machado, Gerzia Maria de Carvalho, Leon, Leonor Laura Pinto
• Format: Journal Article
• Language: English
• Published: Sociedade Brasileira de Química 2011
• Subjects: 6-epiblumenol B; blumenol B; Gustavia elliptica
• ISSN: 0100-4042; 1678-7064
• DOI: 10.1590/S0100-40422011000700015

The phytochemical investigation of the stem bark and leaves of G. elliptica provided a mixture of the norisoprenoids blumenol B and 6-epiblumenol B along with the triterpenes friedelin, as the major constituent, friedelanol, ursa-9(11),12-dien-3-ol, a-amyrin, β-amyrin, morentenol, epifriedelanol, as well as the sesquiterpenes trans-caryophyllene, α-humulene, ethyl hydnocarpate and other fatty acid esters. The identification of the compounds was performed on basis of spectrometric methods such as GC-MS, IR, MS and 1D and 2D NMR. Stem bark extracts showed significant leishmanicidal activity against promastigote forms of Leishmania braziliensis, with the best results for the chloroform extract.