Constituintes químicos de Capraria biflora (Scrophulariaceae) e atividade larvicida de seu óleo essencial

• Published in: Química Nova Vol. 35; no. 11; pp. 2258 - 2262
• Main Authors: Souza, Luciana Gregório da S., Almeida, Macia Cleane S., Monte, Francisco José Q., Santiago, Gilvandete Maria P., Braz-Filho, Raimundo, Lemos, Telma Leda G., Gomes, Clerton L., Nascimento, Ronaldo F. do
• Format: Journal Article
• Language: English
• Published: Sociedade Brasileira de Química 2012
• Subjects: Capraria biflora; chlorinated iridoid; essential oil
• ISSN: 0100-4042; 1678-7064
• DOI: 10.1590/S0100-40422012001100032

Analysis of essential oil from fresh leaves of Capraria biflora allowed identification of fourteen essential oil constituents among which thirteen are sesquiterpene compounds, and α-humulene (43.0%) the major constituent. The essential oil was tested for larvicidal activity against Aedes aegypti showing good activity, with LC50 73.39 µg/mL (2.27 g/mL). Chromatographic studies of extracts from roots and stems allowed the isolation of five compounds: naphthoquinone biflorin, sesquiterpene caprariolide B, the steroid β-sitosterol, the carbohydrate D-mannitol and iridoid myopochlorin first reported in the species C. biflora. The structures of compounds were characterized by spectroscopic data, IR, MS, NMR13C, NMR¹H, NOE, HSQC and HMBC.