Investigation of the anticonvulsant and remyelinating potential of dexketoprofen on a rat model of primary generalized seizures

• Published in: Nevrologii͡a︡, neĭropsikhiatrii͡a︡, psikhosomatika Vol. 12; no. 4; pp. 84 - 90
• Main Authors: Gromova, O. A., Demidov, V. I., Kalacheva, A. G., Torshin, I. Yu, Grishina, T. R., Bogacheva, T. E.
• Format: Journal Article
• Language: English
• Published: IMA-PRESS LLC 27-08-2020
• Subjects: demyelination; gabapentin; neuroprotection; seizures; sodium valproate
• ISSN: 2074-2711; 2310-1342
• DOI: 10.14412/2074-2711-2020-4-84-90

Objective
: to investigate the effect of dexketoprofen on the severity of seizures on a rat model of primary generalized seizures caused by thiosemicarbazide; to evaluate the neuroprotective effect of the drug.
Material and methods
. The investigation was conducted on 72 male albino rats weighing 200–300 g. The animals were given dexketoprofen and/or comparison drugs (gabapentin, sodium valproate) for 5 days, after which the seizure model was reproduced. The effects of the drugs were evaluated from a set of neurological tests and the results of a histopathological examination of the brain.
Results and discussion
. Dexketoprofen reduced the severity, duration, and number of primary generalized seizures and potentiated the anticonvulsant effects of gabapentin and sodium valproate. Histopathological and morphometric examinations of the rat brain showed that dexketoprofen inhibited the formation of irreversible neuronal changes (27.2%; control, 55.7%), by transferring them into reversible changes (47.7%; control, 21.8%).
Conclusion
. The investigation made it possible to conclude that dexketoprofen had a moderate neuroprotective effect neurologically and morphometrically verified.