Translational molecular self-diffusion in magnetic resonance imaging. II. Measurement of the self-diffusion coefficient

Translational molecular self-diffusion in magnetic resonance imaging. II. Measurement of the self-diffusion coefficient

By varying slice-selective gradients in successive data acquisitions, the first in vitro measurements of molecular self-diffusion coefficients were performed in a magnetic resonance imager at 0.35 Tesla. Reasonably accurate measurements were found by the MRI method in comparison with 2.3 T NMR spect...

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Bibliographic Details
Published in:Investigative radiology Vol. 19; no. 6; p. 491
Main Authors: Wesbey, G E, Moseley, M E, Ehman, R L
Format: Journal Article
Language:English
Published: United States 01-11-1984
Subjects:
Diffusion
Humans
Magnetic Resonance Spectroscopy
Weights and Measures
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Summary:By varying slice-selective gradients in successive data acquisitions, the first in vitro measurements of molecular self-diffusion coefficients were performed in a magnetic resonance imager at 0.35 Tesla. Reasonably accurate measurements were found by the MRI method in comparison with 2.3 T NMR spectrometer measurements on the same samples, and in comparison to reported literature values. Thus, in addition to T1, T2, mobile proton density, flow velocity, magnetic susceptibility, and chemical shift, molecular self-diffusion coefficients are now added to the list of biophysical parameters measurable by magnetic resonance imaging in the noninvasive characterization of biological systems.
ISSN:0020-9996
DOI:10.1097/00004424-198411000-00005