Mothers of twins had higher old-age survival than mothers of singletons in Estonian 19th-century birth cohorts

• Published in: Human reproduction (Oxford) Vol. 39; no. 9; pp. 2124 - 2133
• Main Authors: Meitern, R, Gortfelder, M, Puur, A, Hõrak, P
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01-09-2024
• Subjects: senescence; twinning; twins; lifespan; multiple pregnancy; longevity; cost of reproduction; old-age survival; register-based study; post-partum maternal mortality
• ISSN: 0268-1161; 1460-2350; 1460-2350
• DOI: 10.1093/humrep/deae166

Abstract
STUDY QUESTION
Do the mothers of twins and singletons differ regarding post-partum and old-age mortality?
SUMMARY ANSWER
Twin deliveries were associated with higher post-partum maternal mortality than singleton deliveries, but the lifetime post-partum mortality risk was similar for mothers of twins and singletons; survival of twinners was higher than survival of the mothers of singletons after the 67th lifespan percentile.
WHAT IS KNOWN ALREADY
Twinning is typically associated with higher post-partum maternal mortality. The evidence about whether twinning incurs long-term survival costs of reproduction or is a trait pertinent to long-lived women is scarce and contradictory.
STUDY DESIGN, SIZE, DURATION
The study is based on the data of the Estonian Family Register (operating from 1926 to 1943) and involves 5565 mothers of twins and 119 613 mothers of singletons born between 1850 and 1899. The subset for comparing maternal lifespans included 1703–1884 mothers of twins and 19 747–36 690 mothers of singletons.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Post-partum maternal mortality was analyzed in the whole sample (including mothers of a single child) by logistic regression. Most of the analyses were performed in samples where each mother of twins was matched against mothers of singletons based on parity (or number of deliveries), urban versus rural and inland versus coastal origin, whether their lifespan was known, date of birth and age at first birth. Lifespans were compared in linear mixed models. Quantile regression was used to analyze age-dependent variations in maternal mortality rates. All models were adjusted for relevant biodemographic covariates.
MAIN RESULTS AND THE ROLE OF CHANCE
The twinning rate in the whole sample was 4.4%. During the year after giving birth, maternal mortality for twin deliveries was 0.75% (17/2273) and 0.37% (449/122 750) for singleton deliveries (OR = 2.05, 95% CI = 1.21–3.23). However, the lifetime post-partum mortality risk for mothers of twins (0.51%; 28/5557) and singletons (0.37%; 438/119 466) did not differ significantly (OR = 1.38, 95% CI = 0.91–1.98). The life spans of the mothers of twins and singletons did not differ in matched samples. Past the 67th lifespan percentile, the odds of survival were significantly higher for mothers of twins than mothers of singletons, as indicated by non-overlapping 95% confidence intervals.
LIMITATIONS, REASONS FOR CAUTION
Relatively low number of individuals (22 802–28 335) with known age at death in matched datasets due to discontinuation of the register after 1943.
WIDER IMPLICATIONS OF THE FINDINGS
The finding that mothers of twins had higher odds of old-age survival than mothers of singletons is consistent with the contention that twinners represent a non-random subset of women whose robust phenotypic quality allows them to outlive the mothers of singletons in old age.
STUDY FUNDING/COMPETING INTEREST(S)
The study was funded by the Estonian Research Council grants PRG1137, PRG2248, and PSG669. The authors declare no competing interests.
TRIAL REGISTRATION NUMBER
N/A.