Early administration of genetically engineered biological agents for immune-mediated inflammatory diseases: opportunities and prospects. An experts’ opinion

• Published in: Alʹmanakh klinicheskoĭ medit͡s︡iny Vol. 48; no. 6; pp. 422 - 436
• Main Authors: Abdulganieva, D. I., Bakulev, A. L., Belousova, E. A., Veselov, A. V., Korotaeva, T. V., Lila, A. M., Loginova, E. Yu, Sokolovskiy, E. V., Khobeysh, M. M., Shapina, M. V., Shchukina, O. B.
• Format: Journal Article
• Language: English
• Published: MONIKI 29-12-2020
• Subjects: crohn's disease; early administration of biological agents; psoriasis; psoriatic arthritis; ulcerative colitis
• ISSN: 2072-0505; 2587-9294
• DOI: 10.18786/2072-0505-2020-48-050

Psoriasis (Ps), psoriatic arthritis (PsA), and inflammatory bowel diseases (IBDs) are characterized by a  progressive course and commonly result in disability. Therefore, their early diagnosis with the assessment of a  clinical phenotype and unfavorable prognostic factors and the timely initiation of therapy are important. The paper provides the expert consensus on the definition of the early stage of Ps, PsA, and IBDs, their treatment goals and main unfavorable prognostic factors. It also gives the rationale for the early use of biological agents in patients with immune-mediated inflammatory diseases.