5‐Nitrofuryl‐Containing Thiosemicarbazone Gold(I) Compounds: Synthesis, Stability Studies, and Anticancer Activity

• Published in: ChemPlusChem (Weinheim, Germany) Vol. 88; no. 12; pp. e202300500 - n/a
• Main Authors: Rodríguez‐Arce, Esteban, Gavrilov, Eric, Alvite, Ximena, Nayeem, Nazia, León, Ignacio E., Neary, Michelle C., Otero, Lucía, Gambino, Dinorah, Olea Azar, Claudio, Contel, María
• Format: Journal Article
• Language: English
• Published: Germany 01-12-2023
• Subjects: Gold; Humans; Thiosemicarbazones - pharmacology
• ISSN: 2192-6506; 2192-6506
• DOI: 10.1002/cplu.202300500

Invited for this month's cover are the collaborating groups of Esteban Rodríguez‐Arce from the University of Chile and María Contel from The City University of New York Brooklyn College. The cover picture shows “Supergold“ a very powerful gender neutral warrior with superpowers who fights against cancer! The warrior's golden armor and sword represent the pharmacological power of the gold atom. Engraved on the shield, the gold‐thiosemicarbazone molecules are the warrior's coat of arms. Supergold selectively destroys different cancer cells. More information can be found in the Research Article by Esteban Rodríguez‐Arce, María Contel, and co‐workers.
The synthesis of four gold(I) [AuClL] compounds containing chloro and biologically active protonated thiosemicarbazones based on 5‐nitrofuryl (L=HSTC) is reported. The cytotoxicity of the gold compounds and thiosemicarbazone ligands was evaluated against selected cancer cell lines and compared to that of Auranofin. Read more about the story behind the cover in the Cover Profile and about the research itself (DOI: 10.1002/cplu.202300115).